NFL Game of the Week: Bills at Chiefs

NFL Oct 14, 2022

Patrick Mahomes is in a rare spot as a home underdog versus the Bills on Sunday.

It doesn't get any better than Buffalo playing Kansas City.

Arguably the best two teams in football right now (sorry Philadelphia), these two explosive AFC powerhouses have dominated the showcase in recent seasons, seemingly saving their very best games for occasions when they play against each other. Who will ever forget last season's epic high-flying Bills-Chiefs showdown that went into OT?  

Not only is this a rematch of last year’s all-time great playoff game it could also be significant as to who gets home-field advantage in a future playoff meeting later this season.

Kickoff is set for 5:25 p.m. CT on Sunday afternoon at Arrowhead Stadium.

Prediction (powered by

As talented and explosive as the Bills are, it's still surprising to see the Chiefs be a home underdog. This is only the seventh time in the Andy Reid era (2013-present) that his team is getting points at home.

The Chiefs also boast the highest-scoring offense in the league.

So, why is Kansas City an underdog?

Here's an alternative perspective from CBS Sports on that question:

It's fun to debate which one of these teams is the best in the AFC. To me right now, it's the Bills. They have a higher-ranking offense, higher-ranking passing offense, higher-ranking rushing offense, higher-ranking total defense, higher-ranking passing defense and higher-ranking rushing defense. They are the most complete team on both sides of the ball, and possess the kind of depth that's needed from a Super Bowl contender

Kansas City does have a reputation for starting big games slowly and then coming back in the second half. Based on this history, an interesting hedge could be to bet the Bills in the first half and lay a small number but then take the Chiefs +3 for the full game.

The O/U on these games can't be set high enough, it seems. They consistently fly OVER, so betting the high end of 54 might also be worth a look.